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Precautions
Pregnancy and Lactation: - Safe use of fluoxetine during pregnancy and lactation has not been established. Therefore, it should not be administered to women of childbearing potential or nursing mother
s unless, in the opinion of the treating physician, the expected benefits to the patient markedly outweigh the possible hazards to the child or fetus. In 1 breast milk sample, the concentration of flu
oxetine plus norfluoxetine was 70.4 ng/mL. The concentration in the mother's plasma was 295 ng/mL. No adverse effects on the infant were reported.
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Overdose
May be more severe than side effects that may occur from regular doses, or several symptoms may occur together
- Agitation and restlessness; convulsions (seizures); drowsiness; fast heartbeat;
nausea and vomiting; talking, feeling, and acting with excitement and activity you cannot control; trembling or shaking
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Special Wanring
Urogenital:
Frequent: Painful menstruation, sexual dysfunction, urinary tract infection, frequent micturition.
Infrequent: Abnormal ejaculation, impotence, menopause, amenorrhea, menorrh
agia, ovarian disorder, vaginitis, leukorrhea, fibrocystic breast, breast pain, cystitis, dysuria, urinary urgency, urinary incontinence.
Rare: Breast enlargement, galactorrhea, abortion, dy
spareunia, uterine spasm, vaginal hemorrhage, metrorrhagia, hematuria, albuminuria, polyuria, pyuria, epididymitis, orchitis, pyelonephritis, salpingitis, urethritis, kidney calculus, urethral pain, u
rolithiasis.
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Before Taking This Medicine
Pregnancy¡XOne study of babies whose mothers had taken Prozac while they were pregnant found some problems in the babies, such as premature birth, jitteriness, and trouble in breathing or nursing. How
ver, four other studies did not find any problems in babies or young children whose mothers had taken Prozac while they were pregnant. Tell your doctor if you are pregnant or if you may become pregnan
t while you are taking this medicine.
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Why is this medication prescribed?
Prozac is a member of the family of drugs called "selective serotonin re-uptake inhibitors." Serotonin is one of the chemical messengers believed to govern moods. Ordinarily, it is quickly reabsorbed
after its release at the junctures between nerves. Re-uptake inhibitors such as Prozac slow this process, thereby boosting the levels of serotonin available in the brain.
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Significant Interactions:
Tricyclic antidepressants (amitriptyline [e.g., Elavil], amoxapine [e.g., Asendin], clomipramine [e.g., Anafranil], desipramine [e.g., Pertofrane], doxepin [e.g., Sinequan], imipramine [e.g., Tofranil
], nortriptyline [e.g., Aventyl], protriptyline [e.g., Vivactil], trimipramine [e.g., Surmontil])¡XHigher blood levels of these medicines may occur, which increases the chance of having serious side e
fects. Your doctor may want to see you more often and may need to change the doses of your medicines. Also, taking amitriptyline, clomipramine, or imipramine with fluoxetine may increase the chance of
developing the serotonin syndrome
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