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What Is It

For patients using Retin-A for the treatment of acne:
- Regular use of water-based creams or lotions helps to reduce skin irritation or dryness that may be caused by the use of Retin-A.
For patients using Retin-A for the treatment of fine wrinkling, dark spots, and rough skin caused by the sun:
- This medicine should be used as part of an ongoing program to avoid further damage to y our skin from the sun. This program includes staying out of the sun when possible or wearing proper clothing or hats to protect your skin from sunlight.
- Regular use of oil-based creams or lotio ns helps to reduce skin irritation or dryness caused by the use of Retin-A.

Possible Side Effect

In some animal studies, Retin-A has been shown to cause skin tumors to develop faster when the treated area is exposed to ultraviolet light (sunlight or artificial sunlight from a sunlamp). Other stud ies have not shown the same result and more studies need to be done. It is not known if Retin-A causes skin tumors to develop faster in humans.

Check with your doctor as soon as possible if a ny of the following side effects occur:

- Burning feeling or stinging skin (severe); lightening of skin of treated area, unexpected; peeling of skin (severe); redness of skin (severe) ; u nusual dryness of skin (severe)

- Darkening of treated skin

What is this Drug

Your acne probably will get worse (red, scaling skin and an increase in acne sores) during the first 7-10 days that you use this medication. Nevertheless, continue to use it; the acne sores should dis appear. Usually 2-3 weeks (and sometimes more than 6 weeks) of regular use of Retin-A is required before improvement is seen.

Other Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to c hange the dose, or other precautions may be necessary. Tell your health care professional if you are using any other topical prescription or nonprescription (over-the-counter [OTC]) medicine that is t o be applied to the same area of the skin. When you are using topical Retin-A, it is especially important that your health care professional know if you are taking any of the following:

- Ac itretin (e.g., Soriatane)
- Etretinate (e.g., Tegison)
- Retin-A, oral ¡XMay increase chance of getting severe dryness or redness of skin

Cautions

Using these products along with Retin-A may cause mild to severe irritation of the skin. Although skin irritation can occur, some doctors sometimes allow benzoyl peroxide to be used with Retin-A to tr eat acne. Usually Retin-A is applied at night so that it does not cause a problem with any other topical products that you might use during the day. Check with your doctor before using topical medicin es with Retin-A.

What special precautions should I follow?

Pregnancy¡XRetin-A has not been studied in pregnant women. Topical Retin-A is not recommended during pregnancy. Topical Retin-A has been shown to cause delayed bone development in some animal fetuses. Before using this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.


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